The Efficacy of Photodynamic Therapy in Actinic Cheilitis of the Lower Lip: A Prospective Study of 15 Patients
Authors: BERKING, CAROLA1; HERZINGER, THOMAS1; FLAIG, MICHAEL J.1; BRENNER, MICHAELA1; BORELLI, CLAUDIA1; DEGITZ, KLAUS1
Source: Dermatologic Surgery, Volume 33, Number 7, July 2007 , pp. 825-830(6)
Abstract:
BACKGROUND
Photodynamic therapy (PDT) has been developed into a widely used method to treat actinic keratoses and basal cell carcinoma. OBJECTIVE
The objective was to assess the efficacy of PDT in the treatment of actinic cheilitis of the lower lip. METHODS
In this prospective, uncontrolled study at a university dermatology department, 15 patients with actinic cheilitis received two sessions of PDT of the lower lip at an interval of 1 week using methylaminoxopentanoate and red light. Clinical and histopathologic evaluation was performed 3 months after therapy. RESULTS
Complete clinical cure was observed in 47% (7/15) and partial cure in another 47% (7/15) of the patients. By histopathologic analysis, residual disease was found in 62% (8/13). Cosmetic results and patients' satisfaction were good to excellent in most cases. Local pain was sufficiently controlled by local anesthesia. CONCLUSION
PDT can be an effective noninvasive method to treat actinic cheilitis of the lower lip.
5 comments:
Those figures do not seem very impressive to me! However they correspond to my own impression of the treatment. It will remove a lot of the superficial damage but I often have to spot weld with liquid nitrogen at 3 months follow up and they all have to photoprotect afterwards.
interesting that all required local anaesthetic infiltration - i think this is a key point - i remember another dermo who treated himself saying it was virtually intolerable without....agree on ian's point re sunprotection....slop on that 'megan gale invisible zinc'!!
I agree the figures don't sound very impressive Ian. I tend to send patients to a local derm for laser vermillionectomy but have to admit I am not familiar with the reported clearence rates from studies. I would hope it is better than PDT in this study. I will look it up tonight.
I hate lips! Every treatment has a long list of disadvantages, and on these stats PDT is no different. How do you publish numbers like this and call the treatment "effective"?
It is essential to get accurate treatment for Actinic Keratosis problem as it might result in skin cancer. The use of different Actinic Keratosis Herbal Treatment can provide relief from the problem.
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