Papilloma virus and Actinic Keratoses

This study was interesting looking at the potentiation of the developement of actinic keratoses in patients who had associated papilloma virus. Can the study on SCC incidence be far behind? IMCC

Sun-Related Factors, Betapapillomavirus, and Actinic Keratoses
A Prospective Study

Penelope McBride, MBBS, MPhil; Rachel Neale, BVSc, PhD; Nirmala Pandeya, BSc, MMedSc; Adèle Green, MBBS, PhD


Arch Dermatol. 2007;143:862-868.

Objective To examine prospectively the relationship among sun exposure, Betapapillomavirus, and development of actinic keratoses.

Design Prospective, community-based cohort study.

Setting Township of Nambour in Southeast Queensland, Australia.

Participants A total of 291 randomly selected adults aged 36 to 86 years with the presence or absence of Betapapillomavirus DNA in eyebrow hair follicle cells known at baseline in August 1996 and with subsequently documented sun exposure histories.

Main Outcome Measures Prevalence of actinic keratoses in March 2003 after 7 years of follow-up.

Results Beyond the known determinants of multiple actinic keratoses, namely, advanced age, male sex, fair skin, and lifetime occupational sun exposure, Betapapillomavirus infection was associated with having more than 10 actinic keratoses (odds ratio, 1.8; 95% confidence interval, 0.7-4.4). However, Betapapillomavirus positivity led to a significant 13-fold increase in the risk of actinic keratoses among those 60 years or older, a nearly 6-fold increase in risk when combined with fair skin color, and a doubling in risk of actinic keratoses when combined with high sun exposure, recent or cumulative, compared with those who had neither Betapapillomavirus infection nor the respective risk factor of interest.

Conclusions Although the presence of Betapapillomavirus DNA in eyebrow hair follicle cells had only a small independent association with actinic keratoses, Betapapillomavirus infection in combination with key risk factors increased the risk of actinic keratoses, which is consistent with a potentiation by Betapapillomavirus of the effect of established causal factors.